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Smart ligands are affinity ligands selected with pre-defined equilibrium (), kinetic (, ) and thermodynamic (ΔH, ΔS) parameters of biomolecular interaction. Ligands with desired parameters can be selected from large combinatorial libraries of biopolymers using instrumental separation techniques with well-described kinetic behaviour, such as Kinetic capillary electrophoresis (KCE), Surface Plasmon Resonance (SPR), Microscale Thermophoresis (MST), etc. Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set of unique applications in biomedical research, drug discovery and proteomic studies. For example, a panel of DNA smart aptamers has been recently used to develop affinity analysis of proteins with ultra-wide dynamic range of measured concentrations. ==References== * * * * * 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Smart ligand」の詳細全文を読む スポンサード リンク
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