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Smart ligand : ウィキペディア英語版
Smart ligand
Smart ligands are affinity ligands selected with pre-defined equilibrium (K_), kinetic (k_, k_) and thermodynamic (ΔH, ΔS) parameters of biomolecular interaction.
Ligands with desired parameters can be selected from large combinatorial libraries of biopolymers using instrumental separation techniques with well-described kinetic behaviour, such as Kinetic capillary electrophoresis (KCE), Surface Plasmon Resonance (SPR), Microscale Thermophoresis (MST), etc. Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed.
Smart ligands can find a set of unique applications in biomedical research, drug discovery and proteomic studies. For example, a panel of DNA smart aptamers has been recently used to develop affinity analysis of proteins with ultra-wide dynamic range of measured concentrations.
==References==

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抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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